Communication Affichée: Poster tour 2


Le 14/10/2021 de 17:30 à 18:00


Retour Session

P055

Présence de troubles cognitifs à long terme chez l’adulte voyageur après un paludisme sévère de type falciparum.

Hannah Lemistre (Bordeaux, France), Mathilde Carlsberg (Bordeaux, France), Sophie Le Marois (Bordeaux, France), Bertrand Glize (Bordeaux, France)

Objective : Malaria is one of the most common infectious diseases in the world. The plasmodium falciparum accounts for the vast majority of malaria’s infections for which studies showed a predisposition for the central nervous system. Among the populations most at risk for severe manifestations, non-immune adult travelers are the most likely to develop complications during infection. Symptoms are not limited to the infection and studies have shown long-term cognitive sequelae in children. However, very few studies have examined these sequelae in non-immune adults. The four studies found on this topic have found the presence of cognitive deficits and disseminated brain lesions in some adults.
Our aim was to confirm the presence of post-malaria cognitive sequelae in adult travelers from non-endemic areas and to describe the pattern of these sequelaes.
 

Material / Patients and Methods : 7 adult subjects who had presented a first malaria infection between 6 and 24 months before the evaluation were included. In order to screen several cognitive impairments, we used specific tools to explore language, memory and executive functions.
 

Results : 5 patients out of 7 had at least one function affected. Two patients had mild-severe cognitive impairment. We found that cognitive impairments were particularly non localised functions such as inhibition, working memory, episodic memory and language in the affected subjects except for flexibility in which we observed a recurrent impairment (5/7).
 

Discussion - Conclusion : Our results reinforce those of the other studies on this subject. These testifiy that malaria induces cognitive impairment. Specific etiology and mechanisms which lead to these impairment should be explored.
 

Keywords : malaria - falciparum – cognitive impairments – adult traveler – long term – case study