Oncologie et MPR


Le 15/10/2021 de 09:00 à 10:30


Retour Session

CO129

Analyse rétrospective d’évaluations systématiques en épreuve d’effort au 4ème mois post-allogreffe de cellules souches hématopoïétiques.

Antoine Cordival (Toulouse, France), Virgile Pinelli (Toulouse, France), Sarah Guenounou (Toulouse, France), Hélène Dessort (Toulouse, France), Marc Labrunée (Tarbes, France), Darolles Yann (Saint-Orens-de-Gameville, France), Pierre Cerutti (Saint-Orens-de-Gameville, France), Camille Cormier (Toulouse, France)

Objective : Allo-HSCT is the only curative treatment for some hematologic malignancies. No cardio-pulmonary ergometric testing (CPET) data at post-allo-HSCT early stage is currently available. Our aim was to characterize it and identify predictive elements for ergometric abnormalities.

Material / Patients and Methods : 71 patients were evaluated between 2019 and 2021 with CPET, at 120-150 days after allo-HSCT, in Toulouse Oncological University Institute . CPET included step-by-step gas exchanges analysis. First ventilatory threshold and PeakVO2 were recorded. QOL, history, clinical testing and anamnestic data were gathered from medical files.

Results : According to first ventilatory threshold, patients significantly differed regarding neurotoxic or myotoxic drugs administration, myeloablative conditioning, acute lymphoid leukaemia, ciclosporin dosage, GVH reaction, physical activity and 6 minutes walking test. According to peakVO2, patients differed regarding de novo abnormality of functional respiratory testing, clinical amyotrophia, GVH reaction, and 6 minutes walking test.
Patients did not differ on acute complications following allo-HSCT procedure, on SF-36 QOL measurements, or clinical signs.

Discussion - Conclusion : This description highlights several points of interest : Firstly, QOL and patients complaints at this time are not impacted by ergometric parameters. A censorship effect due to post-allo-HSCT environmental safety restriction can be suspected. Secondly, a 6 minutes walking test differed according to the presence of ergometric abnormality. Its value as a screening test could be assessed. Tertially, the nature of ergometric abnormalities can be suspected on HSCT course and could be used to personnalize reeducation.

Keywords : CPET, Allo-HSCT, Hematology, Oncologic Rehabilitation, Quality Of Life

Disclosure of interest : No conflict of interest to declare