CO129
Analyse rétrospective d’évaluations systématiques en épreuve d’effort au 4ème mois post-allogreffe de cellules souches hématopoïétiques.
Antoine
Cordival
(Toulouse, France),
Virgile
Pinelli
(Toulouse, France),
Sarah
Guenounou
(Toulouse, France),
Hélène
Dessort
(Toulouse, France),
Marc
Labrunée
(Tarbes, France),
Darolles
Yann
(Saint-Orens-de-Gameville, France),
Pierre
Cerutti
(Saint-Orens-de-Gameville, France),
Camille
Cormier
(Toulouse, France)
Objective :
Allo-HSCT is the only curative treatment for some hematologic malignancies. No cardio-pulmonary ergometric testing (CPET) data at post-allo-HSCT early stage is currently available. Our aim was to characterize it and identify predictive elements for ergometric abnormalities.
Material / Patients and Methods :
71 patients were evaluated between 2019 and 2021 with CPET, at 120-150 days after allo-HSCT, in Toulouse Oncological University Institute . CPET included step-by-step gas exchanges analysis. First ventilatory threshold and PeakVO2 were recorded. QOL, history, clinical testing and anamnestic data were gathered from medical files.
Results :
According to first ventilatory threshold, patients significantly differed regarding neurotoxic or myotoxic drugs administration, myeloablative conditioning, acute lymphoid leukaemia, ciclosporin dosage, GVH reaction, physical activity and 6 minutes walking test. According to peakVO2, patients differed regarding de novo abnormality of functional respiratory testing, clinical amyotrophia, GVH reaction, and 6 minutes walking test.
Patients did not differ on acute complications following allo-HSCT procedure, on SF-36 QOL measurements, or clinical signs.
Patients did not differ on acute complications following allo-HSCT procedure, on SF-36 QOL measurements, or clinical signs.
Discussion - Conclusion :
This description highlights several points of interest : Firstly, QOL and patients complaints at this time are not impacted by ergometric parameters. A censorship effect due to post-allo-HSCT environmental safety restriction can be suspected. Secondly, a 6 minutes walking test differed according to the presence of ergometric abnormality. Its value as a screening test could be assessed. Tertially, the nature of ergometric abnormalities can be suspected on HSCT course and could be used to personnalize reeducation.
Keywords :
CPET, Allo-HSCT, Hematology, Oncologic Rehabilitation, Quality Of Life
Disclosure of interest :
No conflict of interest to declare