Le 15/10/2021 de 14:00 à 15:30


Retour Session

CO006

Etude MEDULLOSCOL : Mesure IRM du flux médullaire du liquide cérébrospinal dans la Scoliose Idiopathique de l'Adolescent et évaluation de sa signalisation à travers l'étude de la graviception et de la proprioception du tronc - Etude prospective contrôlée avec suivi de cohorte

Guillaume Zavard (Lille, France), Sebastien Verclytte (Lomme, France), Khalid Ambarki (Lomme, France), Martin Catala (Paris, France), Andre Thevenon (Lille, France), Vincent Tiffreau (Lille, France), Jean-François Catanzariti (Villeneuve-d'Ascq, France)

Objective : The pathophysiology of adolescent idiopathic scoliosis (AIS) is misunderstood thus limiting its treatment. In zebrafish, a ciliary dysfunction in the area of the ependyma of the central canal causes a disruption of the cerebrospinal fluid (CSF) flow responsible for a spinal deformation. The proprioceptive system of the mouse appears to be involved in maintaining the spine alignment. In humans, an overall disruption of proprioception and a high prevalence of syringomyelia in AIS have been shown. The hypothesis of AIS is that a genetically determined ciliopathy causes a disturbance of the spinal CSF flow causing a change in the signaling of the medullary ciliated neurons inducing a disturbance of the trunk’s proprioceptive control and a scoliotic curvature. The goal of the study is to know if there is a disturbance in the CSF flow and that may be correlated with proprioception abnormalities in AIS.

Material / Patients and Methods : The characteristics of the CSF flow in phase-contrast MRI between scoliotic adolescents and a healthy group will be studied. Thanks to additional examinations, truncal proprioception and graviception will be measured and compared between the two groups.

Results : We will have to observe a difference in CSF flow associated with proprioception abnormalities of the trunk in the AIS group to confirm the pathophysiological hypothesis of the AIS constitution.

Discussion - Conclusion : This will be the first controlled study on this topic. The first results of this study will be presented at the congress.

Keywords : Scoliosis, Ciliopathy, Cerebrospinal Fluid, proprioception,